Title : Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis.

Pub. Date : 2022 Feb

PMID : 34271060






1 Functional Relationships(s)
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1 The T variant destroys a functional cytosine-phosphate-guanine site, resulting in reduced cytosine-phosphate-guanine methylation at this site (but not neighboring sites) in TT and CT compared with CC primary human keratinocytes and Mechanisms of Progression of Atopic Dermatitis to Asthma in Children children"s skin samples, and rs11652075 increases CARD14 expression in an allele-specific fashion. cytosine-phosphate-guanine caspase recruitment domain family member 14 Homo sapiens