Pub. Date : 2021 Jul 15
PMID : 34267188
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the current study, we found that aberrant activation of mTORC1 was likely attributed to the reduction of DEPDC5 in the livers of ethanol-fed mice or ALD patients. | Ethanol | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | The pathological effect of sustained mTORC1 activity in ALD may be attributed to the suppression of peroxisome proliferator activated receptor alpha (PPARalpha), the master regulator of fatty acid oxidation in hepatocytes, because fenofibrate (PPARalpha agonist) treatment reverses ethanol-induced liver steatosis and inflammation in Depdc5-LKO mice. | Ethanol | CREB regulated transcription coactivator 1 | Mus musculus |