Title : Subcutaneous Adipose Tissue Metabolic Function and Insulin Sensitivity in People With Obesity.

Pub. Date : 2021 Oct

PMID : 34266892






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1 We used stable isotope-labeled glucose and palmitate tracer infusions, a hyperinsulinemic-euglycemic clamp, positron-emission tomography of muscles and adipose tissue after (18F)fluorodeoxyglucose and (15O)water injections, and subcutaneous adipose tissue (SAT) biopsy to test the hypotheses that: i) increased glucose uptake in SAT is responsible for high insulin-stimulated whole-body glucose uptake in people with obesity who are insulin-sensitive, and ii) putative SAT factors thought to cause insulin resistance are present in people with obesity who are insulin-resistant but not in those who are insulin-sensitive. Water insulin Homo sapiens