Title : Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens.

Pub. Date : 2021 Jul

PMID : 34266882






3 Functional Relationships(s)
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1 RESULTS: By testing T-cell recognition of OVA and DBY on a murine B-cell line overexpressing H2-M and H2-O, respectively, we showed that OVA leads to a stronger T-cell activation in the presence of H2-O demonstrating its DM-sensitivity. dm serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
2 RESULTS: By testing T-cell recognition of OVA and DBY on a murine B-cell line overexpressing H2-M and H2-O, respectively, we showed that OVA leads to a stronger T-cell activation in the presence of H2-O demonstrating its DM-sensitivity. dm serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
3 By introducing mutations within the T-cell epitopes we could generate one further DM-sensitive variant of OVA and two DM-resistant counterparts. dm serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus