Title : The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.

Pub. Date : 2022 Mar 29

PMID : 34264340






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1 Finally, we demonstrate that administration of the mTOR inhibitor rapamycin following kindled seizures rescued enhanced remote and long-term memory deficits associated with earlier kindling and prevented the seizure-induced increases in Alzheimer"s disease neuropathology. Sirolimus mechanistic target of rapamycin kinase Mus musculus