Pub. Date : 2021 Sep 30
PMID : 34252390
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) prevented high glucose-induced decreases in SIRT1 and AMPK activity and increased GLUT4 protein expression, thereby improving glucose uptake in podocytes. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | In turn, the enhancement of NOS/NO pathway activity may prevent these deleterious effects of high glucose concentrations, thus bidirectionally stimulating the SIRT1-AMPK reciprocal activation loop. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |