Pub. Date : 2021 Jul 13
PMID : 34244426
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro. | Folic Acid | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | Homo sapiens |