Title : p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.

Pub. Date : 2021 Jul 13

PMID : 34244426






1 Functional Relationships(s)
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1 Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro. Folic Acid methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Homo sapiens