Protein Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Organism Homo sapiens
Gene ID 10797
Gene Symbol

MTHFD2

UniProt P13995 (MTDC_HUMAN)
Relationships Total Number of functionally related compound(s) : 68
Total Number of Articles : 59
Description

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Gene Summary

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

synonyms
  • bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
  • NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
  • NMDMC
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Properties