Title : Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats.

Pub. Date : 2021 Jul

PMID : 34243628






2 Functional Relationships(s)
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1 In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman"s space were observed. Acrylamide tumor necrosis factor Rattus norvegicus
2 This suggests that Taxifolin would prevent kidney tissue from acrylamide-induced damage would be effective in treating acrylamide-induced nephrotoxicity, inhibiting the increase of MDA, IL-1beta and TNF-alpha, and decreasing tGSH associated with acrylamide. Acrylamide tumor necrosis factor Rattus norvegicus