Pub. Date : 2021 Jul 8
PMID : 34238922
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer. | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 2 | Moreover, ANXA6 and EGFR protein expression was correlated in TNBC tissues, and exosomal ANXA6 levels at baseline were lower in patients with highly sensitive TNBC than those with resistant TNBC when treated with first-line gemcitabine-based chemotherapy. | gemcitabine | epidermal growth factor receptor | Homo sapiens |
| 3 | In conclusion, resistant cancer cell-derived exosomes induced gemcitabine resistance via exosomal ANXA6, which was associated with the inhibition of EGFR ubiquitination and degradation. | gemcitabine | epidermal growth factor receptor | Homo sapiens |