Title : Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group.

Pub. Date : 2021 Nov 16

PMID : 34224197






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Most of the previously reported HDAC6 inhibitors have a hydroxamate group as a zinc binding group (ZBG), which coordinates to the catalytic zinc ion of HDAC6. hydroxamate histone deacetylase 6 Homo sapiens
2 Most of the previously reported HDAC6 inhibitors have a hydroxamate group as a zinc binding group (ZBG), which coordinates to the catalytic zinc ion of HDAC6. hydroxamate histone deacetylase 6 Homo sapiens
3 The hydroxamate group is liable to metabolically generate mutagenetic hydroxylamine; therefore, non-hydroxamate HDAC6 inhibitors would be advantageous. hydroxamate histone deacetylase 6 Homo sapiens