Pub. Date : 2021 Jun 30
PMID : 34217791
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mining of microarray data from human and rat placental sources identified the involvement of bile acid metabolism and its significant genes, which were verified by RT-qPCR and western blotting on tissues and treated BeWo cells with the administration of FXR/PXR siRNAs or FXR/PXR agonists. | Bile Acids and Salts | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | Mining of microarray data from human and rat placental sources identified the involvement of bile acid metabolism and its significant genes, which were verified by RT-qPCR and western blotting on tissues and treated BeWo cells with the administration of FXR/PXR siRNAs or FXR/PXR agonists. | Bile Acids and Salts | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | In summary, PEE could induce high bile acid level in maternal serum and its mechanism is associated with the high expression of BCRP/MRP3/OATP2B1 in the placenta through up-regulating PXR and down-regulating FXR, thereby leading to an excessive bile acid transport to maternal blood via the placenta. | Bile Acids and Salts | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | In summary, PEE could induce high bile acid level in maternal serum and its mechanism is associated with the high expression of BCRP/MRP3/OATP2B1 in the placenta through up-regulating PXR and down-regulating FXR, thereby leading to an excessive bile acid transport to maternal blood via the placenta. | Bile Acids and Salts | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |