Pub. Date : 2021 Sep
PMID : 34212455
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MK-1775 synergized with CDDP to block proliferation, inducing apoptosis and mitotic catastrophe in TP53-mutant UC cells but not in TP53-wild-type cells. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | Knocking down TP53 in TP53-wild-type cells induced synergism of MK-1775 and CDDP. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | Knocking down TP53 in TP53-wild-type cells induced synergism of MK-1775 and CDDP. | Cisplatin | tumor protein p53 | Homo sapiens |
| 4 | In UMUC3 cell xenografts and two patient-derived xenograft lines with MDM2 overexpression, in which the p53/cell cycle pathway was inactivated, AZD-1775 combined with CDDP suppressed tumor growth inducing both M-phase entry and apoptosis, whereas AZD-1775 alone was as effective as the combination in RT4 cell xenografts. | Cisplatin | tumor protein p53 | Homo sapiens |
| 5 | Differential anti-tumor efficacy of WEE1 blockade alone or combined with CDDP may exist according to p53/cell cycle pathway activity, which may be predictable using an ex vivo 3D primary culture system. | Cisplatin | tumor protein p53 | Homo sapiens |