PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34212455-5	2021	MK-1775 synergized with CDDP to block proliferation, inducing apoptosis and mitotic catastrophe in TP53-mutant UC cells but not in TP53-wild-type cells.	Cisplatin	24-28	tumor protein p53	Homo sapiens	99-103	
34212455-6	2021	Knocking down TP53 in TP53-wild-type cells induced synergism of MK-1775 and CDDP.	Cisplatin	76-80	tumor protein p53	Homo sapiens	14-18	
34212455-6	2021	Knocking down TP53 in TP53-wild-type cells induced synergism of MK-1775 and CDDP.	Cisplatin	76-80	tumor protein p53	Homo sapiens	22-26	
34212455-7	2021	In UMUC3 cell xenografts and two patient-derived xenograft lines with MDM2 overexpression, in which the p53/cell cycle pathway was inactivated, AZD-1775 combined with CDDP suppressed tumor growth inducing both M-phase entry and apoptosis, whereas AZD-1775 alone was as effective as the combination in RT4 cell xenografts.	Cisplatin	167-171	tumor protein p53	Homo sapiens	104-107	
34212455-11	2021	Differential anti-tumor efficacy of WEE1 blockade alone or combined with CDDP may exist according to p53/cell cycle pathway activity, which may be predictable using an ex vivo 3D primary culture system.	Cisplatin	73-77	tumor protein p53	Homo sapiens	101-104