Title : Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner.

Pub. Date : 2021 Aug

PMID : 34212313






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRalpha signal in an AMPK-dependent manner. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens
2 This activation upregulats LXRalpha and its targets, including ABCA1, ABCG1 and SR-BI, which significantly inhibits foam cell formation and promotes cholesterol efflux. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens