Pub. Date : 2021 Jun 20
PMID : 34203110
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent experiments have shown that the HP1a sequence of Drosophila melanogaster can undergo liquid-liquid phase separation under both in vitro and in vivo conditions, induced by changes of the monovalent salt concentration. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 2 | While the phase separation of HP1a is thought to be the mechanism underlying chromatin compartmentalization, the molecular level mechanistic picture of salt-driven phase separation of HP1a has remained poorly understood. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 3 | The disordered hinge region of HP1a is seen as the driver of salt-induced condensation because of its charge enriched sequence and post-translational modifications. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 4 | Here, we set out to decipher the mechanisms of salt-induced condensation of HP1a through a systematic study of salt-dependent conformations of single chains and fuzzy dimers of disordered HP1a hinge sequences. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 5 | Here, we set out to decipher the mechanisms of salt-induced condensation of HP1a through a systematic study of salt-dependent conformations of single chains and fuzzy dimers of disordered HP1a hinge sequences. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 6 | Here, we set out to decipher the mechanisms of salt-induced condensation of HP1a through a systematic study of salt-dependent conformations of single chains and fuzzy dimers of disordered HP1a hinge sequences. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 7 | Furthermore, we find that salt-induced changes in the ensemble of conformations of HP1a disordered hinge sequence fine-tune the inter-chain vs. self-chain interactions in ways that favor fuzzy dimer formation under low salt conditions in the agreement with condensation trends seen in experiments. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |
| 8 | Furthermore, we find that salt-induced changes in the ensemble of conformations of HP1a disordered hinge sequence fine-tune the inter-chain vs. self-chain interactions in ways that favor fuzzy dimer formation under low salt conditions in the agreement with condensation trends seen in experiments. | Salts | Suppressor of variegation 205 | Drosophila melanogaster |