Pub. Date : 2021 Jun 8
PMID : 34201404
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The consequential changes in extracellular glycine concentration can lead to parallel changes in the activity of NR1/NR2B type NMDA receptors of which glycine is a mandatory agonist, and thereby may reduce neurodegenerative events in the retina. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |
| 2 | The consequential changes in extracellular glycine concentration can lead to parallel changes in the activity of NR1/NR2B type NMDA receptors of which glycine is a mandatory agonist, and thereby may reduce neurodegenerative events in the retina. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |
| 3 | We have hypothesized that glycine transporter 1 inhibitors and P2Y purinoceptor agonists may have therapeutic importance in neurodegenerative-neuroinflammatory disorders of the retina by decreasing NR1/NR2B NMDA receptor activity and production and release of a series of proinflammatory cytokines from microglial cells. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |