Title : Crystallography, Molecular Modeling, and COX-2 Inhibition Studies on Indolizine Derivatives.

Pub. Date : 2021 Jun 10

PMID : 34200764






1 Functional Relationships(s)
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1 All the compounds showed activity in micromolar ranges, and the compound diethyl 3-(4-cyanobenzoyl)-7-methoxyindolizine-1,2-dicarboxylate (5a) emerged as a promising COX-2 inhibitor with an IC50 of 5.84 microM, as compared to indomethacin (IC50 = 6.84 microM). Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens