Title : Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology.

Pub. Date : 2021 Dec 16

PMID : 34196664






1 Functional Relationships(s)
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1 In the current study, we used doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model and determined effects of PNU-125096, a positive allosteric modulator of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) on Tat-induced behavioral impairments and neuropathologies. Acetylcholine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus