Title : Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation.

Pub. Date : 2021

PMID : 34194230






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation. celastrol ribonucleotide reductase regulatory subunit M2 Homo sapiens
2 Celastrol modulated many signaling genes and its cytotoxic effect was mainly mediated via over-expression of ATF3 and DDIT3, and down-expression of RRM2 and MCM4. celastrol ribonucleotide reductase regulatory subunit M2 Homo sapiens