Title : Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl4-induced acute liver injury.

Pub. Date : 2021 Sep

PMID : 34191077






2 Functional Relationships(s)
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1 Studies with hepatocyte specific ERRgamma knockout mice or treatment with an ERRgamma-specific inverse agonist, GSK5182 (40 mg/kg), indicated that CCl4-induced hepatic TGF-beta2 production is ERRgamma dependent. GSK5182 transforming growth factor, beta 2 Mus musculus
2 Finally, GSK5182 diminished CCl4-induced fibrogenic response through inhibition of ERRgamma-mediated TGF-beta2 production. GSK5182 transforming growth factor, beta 2 Mus musculus