| Protein Name | transforming growth factor, beta 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 21808 |
| Gene Symbol | Tgfb2 |
| UniProt | P27090 (TGFB2_MOUSE), A0A0A6YXU9 (A0A0A6YXU9_MOUSE), Q3TWH5 (Q3TWH5_MOUSE), Q8CDZ9 (Q8CDZ9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
111
Total Number of Articles : 106 |
Description |
transforming growth factor, beta 2 |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] |
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