Title : Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis.

Pub. Date : 2021 Oct

PMID : 34190354






1 Functional Relationships(s)
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1 Under LPS or IL-4 stimulation, high glucose culture of RAW264.7 elevated ROS level and increased the expression of M1 macrophage markers (iNOS, TNF-alpha, and IL-6) whereas decreased the expression of M2 macrophage markers (Arg-1 and CD206). Glucose nitric oxide synthase 2 Rattus norvegicus