Title : Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution.

Pub. Date : 2021 Aug 20

PMID : 34186208






1 Functional Relationships(s)
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1 Mass spectrometry (MS) revealed that in NADPH pre-reduced TrxR1 but not oxidized TrxR1, the highly active Sec498 of wild-type TrxR1 was arylated by menadione and strongly impaired the DTNB reducing activity in a dose-dependent manner. NADP thioredoxin reductase 1 Homo sapiens