| Protein Name | thioredoxin reductase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7296 |
| Gene Symbol | TXNRD1 |
| UniProt | Q16881 (TRXR1_HUMAN), B7Z2S5 (B7Z2S5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
505
Total Number of Articles : 604 |
Description |
thioredoxin reductase 1 |
| Gene Summary |
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017] |
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