Title : Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.

Pub. Date : 2021 Jul 12

PMID : 34185081






3 Functional Relationships(s)
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1 Here, we demonstrate that activation of caspase-8 and the JNK pathway are mechanisms underlying Cd-induced Fas-mediated activation of the mitochondrial apoptotic pathway in rat cerebral cortical neurons. Cadmium mitogen-activated protein kinase 8 Rattus norvegicus
2 In vitro, Cd induced apoptosis in primary cortical neurons by activating caspase-8, JNK, and the mitochondrial apoptotic pathway. Cadmium mitogen-activated protein kinase 8 Rattus norvegicus
3 Fas knockdown enhanced cell viability in the presence of Cd, and inhibited apoptosis by blocking Cd-activated Fas, caspase-8, and JNK. Cadmium mitogen-activated protein kinase 8 Rattus norvegicus