Pub. Date : 2021 Sep
PMID : 34183378
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silybin restored CYP3A expression through the SIRT2/NF-kappaB pathway in mouse nonalcoholic fatty liver disease. | Silybin | sirtuin 2 | Mus musculus |
| 2 | Moreover, silybin suppressed liver inflammation in HFD-fed mice and inhibited NF-kappaB translocation into the nucleus through elevation of SIRT2 expression and promotion of p65 deacetylation. | Silybin | sirtuin 2 | Mus musculus |
| 3 | In summary, silybin increased NAD+ concentration, promoted SIRT2 expression and lowered p65 acetylation both in vivo and in vitro, which supported the recovery of CYP3A expression. | Silybin | sirtuin 2 | Mus musculus |
| 4 | In the treatment of NAFLD, silybin restored, not inhibited, CYP3A expression and activity through the NAD+/SIRT2 pathway in accordance with its anti-inflammatory effect. | Silybin | sirtuin 2 | Mus musculus |