Title : MicroRNA-122 overexpression promotes apoptosis and tumor suppressor gene expression induced by microcystin-leucine arginine in mouse liver.

Pub. Date : 2021 Jun 28

PMID : 34180736






4 Functional Relationships(s)
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1 Previous studies found that the expression of miR-122 was reduced after MC-LR exposure in liver. mc-lr microRNA 122 Mus musculus
2 Under MC-LR exposure, miR-122 agomir transfection could further increase the expressions of tumor suppressor genes and the release of cytochrome-c (Cyt-c) and decrease the expressions of Bcl-2 and Bcl-w. mc-lr microRNA 122 Mus musculus
3 In conclusion, miR-122 reduction can mitigate MC-LR-induced apoptosis to a certain extent, which in turn, it is likely to have contributed to MC-LR-induced hepatocarcinogenesis. mc-lr microRNA 122 Mus musculus
4 In conclusion, miR-122 reduction can mitigate MC-LR-induced apoptosis to a certain extent, which in turn, it is likely to have contributed to MC-LR-induced hepatocarcinogenesis. mc-lr microRNA 122 Mus musculus