Title : Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant.

Pub. Date : 2021 Jul 8

PMID : 34170697






1 Functional Relationships(s)
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1 Efficient coupling to localized NADP(H) enables IDH activity to be energized, controlled, and monitored in real time, leading directly to a thermodynamic redox landscape for accumulation of the oncometabolite, 2-hydroxyglutarate, that would occur in biological environments when the R132H variant is present. alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens