Title : Modification of amyloid-beta peptide aggregation via photoactivation of strained Ru(ii) polypyridyl complexes.

Pub. Date : 2021 Apr 24

PMID : 34163842






1 Functional Relationships(s)
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1 Both Ru1 and Ru2 contain an extended planar imidazo(4,5-f)(1,10)phenanthroline ligand, as compared to a 2,2"-bipyridine ligand for Ru3, and we show that the presence of the phenanthroline ligand promotes covalent binding to Abeta peptide His residues, and in addition, leads to a pronounced effect on peptide aggregation immediately after photoactivation. Histidine amyloid beta precursor protein Homo sapiens