Title : The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells.

Pub. Date : 2021 Jun

PMID : 34156680






1 Functional Relationships(s)
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1 Intraperitoneal injection 30 mg/kg of TEPP-46 significantly inhibited the development of MCD diet-induced NASH, alleviated the pathological changes in the liver, improved liver function, promoted the expression of the PKM2 tetramer in KCs, and inhibited the expression of HIF-1alpha and NLRP3. TEPP-46 NLR family, pyrin domain containing 3 Mus musculus