Pub. Date : 2021 Jun
PMID : 34156680
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |
| 2 | OBJECTIVE: The present study aimed to investigate the effect and molecular mechanism of the PKM2 small molecule agonist TEPP-46 on the development of methionine choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) in mice. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |
| 3 | Intraperitoneal injection 30 mg/kg of TEPP-46 significantly inhibited the development of MCD diet-induced NASH, alleviated the pathological changes in the liver, improved liver function, promoted the expression of the PKM2 tetramer in KCs, and inhibited the expression of HIF-1alpha and NLRP3. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |
| 4 | CONCLUSIONS: This study demonstrated that TEPP-46, a small molecule agonist of PKM2, may inhibit the nuclear translocation of PKM2 and the activation of KCs by promoting the expression of PKM2 tetramers in KCs, thus inhibiting the development of MCD diet-induced NASH in mice. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |
| 5 | CONCLUSIONS: This study demonstrated that TEPP-46, a small molecule agonist of PKM2, may inhibit the nuclear translocation of PKM2 and the activation of KCs by promoting the expression of PKM2 tetramers in KCs, thus inhibiting the development of MCD diet-induced NASH in mice. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |
| 6 | CONCLUSIONS: This study demonstrated that TEPP-46, a small molecule agonist of PKM2, may inhibit the nuclear translocation of PKM2 and the activation of KCs by promoting the expression of PKM2 tetramers in KCs, thus inhibiting the development of MCD diet-induced NASH in mice. | TEPP-46 | pyruvate kinase, muscle | Mus musculus |