Title : Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice.

Pub. Date : 2021 Aug 25

PMID : 34153226






1 Functional Relationships(s)
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1 Non-cytotoxic concentrations of AGEs upregulated the protein expression of fibronectin, vimentin, and alpha-smooth muscle actin (alpha-SMA) (mesenchymal/myofibroblast markers) and downregulated the protein expression of vascular endothelial (VE)-cadherin and cluster of differentiation (CD) 31 (endothelial cell markers) in cultured mouse pancreatic islet endothelial cells, which was prevented by the AGE cross-link breaker alagebrium chloride. alagebrium actin alpha 2, smooth muscle, aorta Mus musculus