Title : Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo.

Pub. Date : 2021

PMID : 34149427






1 Functional Relationships(s)
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1 We demonstrated that celastrol inhibited the receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis and the bone resorptive function of osteoclasts in vitro by inhibiting the activation of transforming growth factor beta-activated kinase 1-mediated NF-kappaB and mitogen-activated protein kinase signaling pathways and downregulating osteoclastogenesis marker-related genes. celastrol nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus