Title : IGF-1 receptor is involved in the regulatory effects of icariin and icaritin in astrocytes under basal conditions and after an inflammatory challenge.

Pub. Date : 2021 Sep 5

PMID : 34147477






3 Functional Relationships(s)
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1 Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). icariin tumor necrosis factor Homo sapiens
2 Our results showed that both icariin and icaritin significantly inhibited LPS-induced mRNA expressions of tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). icariin tumor necrosis factor Homo sapiens
3 Pre-treatment with IGF-1 receptor antagonist JB-1 could significantly block the anti-inflammatory effects of icariin and icaritin on LPS-induced up-regulations of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). icariin tumor necrosis factor Homo sapiens