Title : Anti-melanogenesis and anti-tyrosinase properties of aryl-substituted acetamides of phenoxy methyl triazole conjugated with thiosemicarbazide: Design, synthesis and biological evaluations.

Pub. Date : 2021 Sep

PMID : 34140181






3 Functional Relationships(s)
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1 A series of aryl phenoxy methyl triazole conjugated with thiosemicarbazides were designed, synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa and l-tyrosine as substrates. Tyrosine tyrosinase Homo sapiens
2 Among the derivatives, compound 9j bearing benzyl displayed exceptionally high potency against tyrosinase with IC50 value of 0.11 muM and 0.17 muM in the presence of l-tyrosine and l-dopa as substrates which is significantly lower than that of kojic acid as the positive control with an IC50 value of 9.28 muM for l-tyrosine and 9.30 muM for l-dopa. Tyrosine tyrosinase Homo sapiens
3 Among the derivatives, compound 9j bearing benzyl displayed exceptionally high potency against tyrosinase with IC50 value of 0.11 muM and 0.17 muM in the presence of l-tyrosine and l-dopa as substrates which is significantly lower than that of kojic acid as the positive control with an IC50 value of 9.28 muM for l-tyrosine and 9.30 muM for l-dopa. Tyrosine tyrosinase Homo sapiens