Pub. Date : 2021 Sep
PMID : 34140181
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | A series of aryl phenoxy methyl triazole conjugated with thiosemicarbazides were designed, synthesized, and evaluated for their tyrosinase inhibitory activities in the presence of l-dopa and l-tyrosine as substrates. | Tyrosine | tyrosinase | Homo sapiens |
2 | Among the derivatives, compound 9j bearing benzyl displayed exceptionally high potency against tyrosinase with IC50 value of 0.11 muM and 0.17 muM in the presence of l-tyrosine and l-dopa as substrates which is significantly lower than that of kojic acid as the positive control with an IC50 value of 9.28 muM for l-tyrosine and 9.30 muM for l-dopa. | Tyrosine | tyrosinase | Homo sapiens |
3 | Among the derivatives, compound 9j bearing benzyl displayed exceptionally high potency against tyrosinase with IC50 value of 0.11 muM and 0.17 muM in the presence of l-tyrosine and l-dopa as substrates which is significantly lower than that of kojic acid as the positive control with an IC50 value of 9.28 muM for l-tyrosine and 9.30 muM for l-dopa. | Tyrosine | tyrosinase | Homo sapiens |