Pub. Date : 2021 Jul
PMID : 34140067
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism. | Menthol | interleukin 25 | Homo sapiens |
| 2 | Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism. | Menthol | interleukin 25 | Homo sapiens |
| 3 | Results Compared with the blank control group, the mRNA and protein expression of IL-25, IL-33 and TSLP, the level of Ca2+, and the protein expression of NF-kappaB p65 were significantly up-regulated in the menthol group. | Menthol | interleukin 25 | Homo sapiens |
| 4 | After knock-down of TRPM8, the menthol-induced increases of Ca2+, IL-25, IL-33, TSLP and NF-kappaB p65 expression were inhibited. | Menthol | interleukin 25 | Homo sapiens |
| 5 | Both BAPTA-AM and PDTC could inhibit the high expression of IL-25, IL-33 and TSLP induced by menthol. | Menthol | interleukin 25 | Homo sapiens |
| 6 | Conclusion Menthol can induce the secretion of IL-25, IL-33 and TSLP in human BEAS-2B cells by activating TRPM8 which leads to increased Ca2+ concentration and activation of the NF-kappaB pathway. | Menthol | interleukin 25 | Homo sapiens |