Title : Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16.

Pub. Date : 2021 Jun 29

PMID : 34131072






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The SARS-CoV-2 genome encodes the 2"-O-methyltransferase nsp16, which, when bound to the coactivator nsp10, uses S-adenosylmethionine (SAM) as a donor to transfer a methyl group to the first ribonucleotide of the mRNA in the final step of viral mRNA capping. S-Adenosylmethionine ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2
2 The SARS-CoV-2 genome encodes the 2"-O-methyltransferase nsp16, which, when bound to the coactivator nsp10, uses S-adenosylmethionine (SAM) as a donor to transfer a methyl group to the first ribonucleotide of the mRNA in the final step of viral mRNA capping. S-Adenosylmethionine ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2