Title : Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.

Pub. Date : 2021 Sep

PMID : 34126350






3 Functional Relationships(s)
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1 The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts. 3,4-dihydroxyphenylethanol interleukin 6 Mus musculus
2 Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated IL-6 release. 3,4-dihydroxyphenylethanol interleukin 6 Mus musculus
3 Hydroxytyrosol suppressed the TNF-alpha-induced mRNA expressions of M-CSF and IL-6. 3,4-dihydroxyphenylethanol interleukin 6 Mus musculus