Pub. Date : 2021
PMID : 34122329
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages. | Cholesterol | caveolin 1 | Homo sapiens |
| 2 | Although the role of Cav-1 in cellular cholesterol homeostasis and vascular inflammation has been reported, the connection between LXR transcriptional activity and Cav-1 expression and function in macrophages has not been investigated. | Cholesterol | caveolin 1 | Homo sapiens |
| 3 | As a result, Cav-1 participates in LXR-dependent cholesterol efflux and the control of inflammatory responses. | Cholesterol | caveolin 1 | Homo sapiens |
| 4 | Together, our data show modulation of the LXR-Cav-1 axis could be exploited to control exacerbated inflammation and cholesterol overload in the macrophage during the pathogenesis of lipid and immune disorders, such as atherosclerosis. | Cholesterol | caveolin 1 | Homo sapiens |