Protein Name caveolin 1
Organism Homo sapiens
Gene ID 857
Gene Symbol


UniProt Q03135 (CAV1_HUMAN), Q7Z4F3 (Q7Z4F3_HUMAN), Q2TNI1 (Q2TNI1_HUMAN), A0A024R757 (A0A024R757_HUMAN), A9XTE5 (A9XTE5_HUMAN), Q59E85 (Q59E85_HUMAN)
Relationships Total Number of functionally related compound(s) : 2406
Total Number of Articles : 2109

caveolin 1

Gene Summary

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

  • caveolin-1
  • caveolin 1, caveolae protein, 22kDa
  • cell growth-inhibiting protein 32
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