Pub. Date : 2021 Jun
PMID : 34114395
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol induces caspase-dependent apoptosis of hepatocellular carcinoma cells by suppression of mammalian target of rapamycin. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Western blot assays indicated that celastrol up-regulated cleaved-caspase-3, cleaved-caspase-8, cleaved-caspase-9, and cleaved-PARP by inhibiting the phosphorylation of mTOR in HepG2 cells. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Celastrol also induced caspase-dependent apoptosis (up-regulation of cleaved-caspase- 3, -8, -9, and cleaved-PARP) and inhibited the activation of mTOR in vivo. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | CONCLUSION: Celastrol induces caspase-dependent apoptosis in HCC cells by inhibiting the activation of mTOR. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |