Title : Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells.

Pub. Date : 2021 Jul

PMID : 34110637






5 Functional Relationships(s)
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1 Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. Palmitic Acid insulin Homo sapiens
2 Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Palmitic Acid insulin Homo sapiens
3 Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes. Palmitic Acid insulin Homo sapiens
4 Cumulative evidence has demonstrated the participation of PA in the molecular cascade underlying cellular insulin resistance in peripheral tissues, but its role in the development of neuronal insulin resistance and the mechanisms involved are not fully understood. Palmitic Acid insulin Homo sapiens
5 In the present work, we have found that neurons differentiated from human neuroblastoma MSN exposed to high but nontoxic concentrations of PA generate ATP through mitochondrial metabolism, which is associated with an increase in the cytosolic Ca2+ and diminished insulin signaling in neurons. Palmitic Acid insulin Homo sapiens