Pub. Date : 2021 Jul
PMID : 34107386
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Besides, resveratrol can activate PI3K/AKT signaling pathway. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | PI3K siRNA can inhibit the PI3K/AKT signaling mediated by resveratrol. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | In conclusion, our study shows that resveratrol can reduce ROS in cardiomyocytes by PI3K/AKT signaling pathway activation, and effectively inhibit the apoptosis of cardiomyocytes, thus having a direct protective effect on cardiomyocytes under SR. | Resveratrol | AKT serine/threonine kinase 1 | Rattus norvegicus |