Pub. Date : 2021 May-Jun
PMID : 34104149
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of ABCB1 gene polymorphism on concentration to dose ratio and adverse effects of tacrolimus in Pakistani liver transplant recipients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Objective: To evaluate the possible association of ABCB1 single nucleotide polymorphism (SNPs) of the ABCB1 gene with tacrolimus dosages, concentration-to-dose ratios (CDR) and adverse effects in Pakistani liver transplant recipients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Objective: To evaluate the possible association of ABCB1 single nucleotide polymorphism (SNPs) of the ABCB1 gene with tacrolimus dosages, concentration-to-dose ratios (CDR) and adverse effects in Pakistani liver transplant recipients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Results: ABCB1 rs1045642 CC genotype showed lower tacrolimus CDR as compared to CT and TT genotype in the first week of the post-transplantation period (p=0.02). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Conclusion: Identification of ABCB1 rs1045642 polymorphism may shorten the time to achieve optimum levels of tacrolimus during dose titration. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | ABCB1 polymorphism rs1045642, rs2032582 and rs1128503 may predict adverse effects in liver transplant recipients receiving tacrolimus. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |