Pub. Date : 2021 Jul 15
PMID : 34103301
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of this study is to identify co-occurring mutations that influence clinical response to the novel FLT3 inhibitor pexidartinib (PLX3397). | pexidartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 2 | The purpose of this study is to identify co-occurring mutations that influence clinical response to the novel FLT3 inhibitor pexidartinib (PLX3397). | pexidartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 3 | EXPERIMENTAL DESIGN: We performed targeted sequencing of pretreatment blasts from 29 patients with FLT3 internal tandem duplication (ITD) mutations treated on the phase I/II trial of pexidartinib in relapsed/refractory FLT3-ITD+ acute myeloid leukemia (AML). | pexidartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 4 | Expression of the Q276* and T283A mutations in FLT3-ITD MV4;11 cells conferred resistance to apoptosis, decreased cell-cycle arrest, and increased proliferation in the presence of pexidartinib and other FLT3 inhibitors. | pexidartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |