Title : Intracellular Ca2+ signaling and ORAI calcium release-activated calcium modulator 1 are associated with hepatic lipidosis in dairy cattle.

Pub. Date : 2021 Jul 1

PMID : 34100951






1 Functional Relationships(s)
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1 In a subsequent study, hepatocytes were transfected with small interfering RNA (siORAI1) or the ORAI1 inhibitor BTP2 for 48 h or 2 h followed by a challenge with the 1.2 mM mixture of fatty acids for 6 h. Compared with control group, silencing or inhibition of ORAI1 led to decreased abundance of fatty acid synthesis (FASN, SREBP1 and ACACA) and ER stress-related proteins in bovine hepatocytes. Fatty Acids fatty acid synthase Bos taurus