Title : Efficient Synthesis and Biological Evaluation of 6-Trifluoroethoxy Functionalized Pteridine Derivatives as EGFR Inhibitors.

Pub. Date : 2022

PMID : 34097593






1 Functional Relationships(s)
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1 Molecular docking model displayed a hydrogen bond between Met-769 amide nitrogen and N-1 in pteridine motif of 7m which lay at the ATP binding site of EGFR kinase domain. Hydrogen epidermal growth factor receptor Homo sapiens