Title : Losartan protects against osteoarthritis by repressing the TGF-β1 signaling pathway via upregulation of PPARγ.

Pub. Date : 2021 Jul

PMID : 34094856






1 Functional Relationships(s)
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1 Losartan treatment or PPARgamma activation contributes to reduced levels of IL-6, IL-1beta, TNF-alpha, and COX-2, expression of TGF-beta1, MMP-13, ADAMTS-4, ADAMTS-5, HtrA1, and iNOS, along with reduced Smad2 and Smad3 phosphorylation, but elevated PPARgamma and Collagen II expression in vivo and in vitro. Losartan interleukin 6 Mus musculus