Title : L-[2,5-H2]phenylalanine, an alternate substrate for rat liver phenylalanine hydroxylase.

Pub. Date : 1988 May 17

PMID : 3408719






5 Functional Relationships(s)
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1 The phenylalanine analogue L-[2,5-H2]phenylalanine (1) was found to be a viable substrate (KM = 0.45 mM, kcat = 8 s-1) for L-phenylalanine-activated, rat liver phenylalanine hydroxylase (EC 1.14.16.1) (PAH). Phenylalanine phenylalanine hydroxylase Rattus norvegicus
2 The phenylalanine analogue L-[2,5-H2]phenylalanine (1) was found to be a viable substrate (KM = 0.45 mM, kcat = 8 s-1) for L-phenylalanine-activated, rat liver phenylalanine hydroxylase (EC 1.14.16.1) (PAH). Phenylalanine phenylalanine hydroxylase Rattus norvegicus
3 The phenylalanine analogue L-[2,5-H2]phenylalanine (1) was found to be a viable substrate (KM = 0.45 mM, kcat = 8 s-1) for L-phenylalanine-activated, rat liver phenylalanine hydroxylase (EC 1.14.16.1) (PAH). Phenylalanine phenylalanine hydroxylase Rattus norvegicus
4 The phenylalanine analogue L-[2,5-H2]phenylalanine (1) was found to be a viable substrate (KM = 0.45 mM, kcat = 8 s-1) for L-phenylalanine-activated, rat liver phenylalanine hydroxylase (EC 1.14.16.1) (PAH). Phenylalanine phenylalanine hydroxylase Rattus norvegicus
5 The enzymatic epoxidation of 1 is consistent with the hypothesis of an intermediate arene oxide on the reaction coordinate for PAH hydroxylation of L-phenylalanine. Phenylalanine phenylalanine hydroxylase Rattus norvegicus